Product Detailed Description

Liposomal magnesium gluconate 80% — High Bioavailability Gentle Magnesium Supplement

Product Overview

liposomal Magnesium Gluconate 80% is a premium-grade dietary supplement ingredient delivering magnesium gluconate in an advanced liposomal delivery system. Magnesium gluconate (CAS 3632-91-5 for anhydrous; CAS 59625-89-7 for dihydrate) is the magnesium salt of D-gluconic acid, chemically designated as D-gluconic acid, magnesium salt (2:1). The anhydrous form has the molecular formula C₁₂H₂₂MgO₁₄ and a molecular weight of 414.60 g/mol, while the dihydrate form has a molecular weight of 450.63 g/mol.

Magnesium is the fourth most abundant cation in the human body and serves as an essential cofactor for more than 300 enzymatic reactions, including all enzymatic processes involving ATP. It plays a critical role in neurochemical transmission and muscular excitability, and is essential for maintaining normal bone density, cardiac rhythmicity, pulmonary function, and blood glucose regulation. Magnesium gluconate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability and excellent gastrointestinal tolerability.

Why Liposomal Technology?

Magnesium gluconate already offers superior bioavailability compared to inorganic magnesium salts such as magnesium oxide, with a landmark study using stable isotope tracers demonstrating that organic magnesium forms, with gluconate ranking highest, achieved absorption rates of 50% to 67% compared to lower absorption for inorganic forms. However, even well-absorbed magnesium salts face challenges related to the saturable nature of intestinal magnesium transport and the potential for gastrointestinal discomfort at higher doses.

Liposomal encapsulation provides four critical advantages:

1. Superior Bioavailability and Absorption — Liposomal formulation technology results in greater absorption and bioavailability of active substances. Liposomal magnesium gluconate has been shown to ensure 8 times greater absorption and bioavailability of the active substances compared to conventional formulations. The liposomal delivery system protects the active substance from oxidation and degradation in the acidic pH of the stomach and increases absorption and bioavailability compared to free and other conventional pharmaceutical carriers.

2. Gastrointestinal Protection — The phospholipid bilayer shields the magnesium-gluconate complex from premature interaction with gastric contents, protecting the active substance from degradation. This minimizes direct contact between magnesium and the gastrointestinal mucosa, reducing the risk of the laxative effect and gastrointestinal discomfort frequently associated with conventional magnesium supplements.

3. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism complements the aqueous transport pathways utilized by free magnesium, supporting enhanced systemic absorption and intracellular delivery.

4. Synergistic Gluconate Anion Activity — Magnesium gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to magnesium sulfate, suggesting a contribution of the gluconate anion to cardioprotection. Magnesium gluconate may serve as a more advantageous magnesium salt for clinical use due to its additional anti-radical and cytoprotective activities.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% magnesium gluconate, with USP-grade purity of 98.0%–102.0% on the anhydrous basis.

• Liposomal Enhancement — Phospholipid bilayer encapsulation protects the magnesium-gluconate complex from gastric degradation and enhances cellular delivery, achieving up to 8 times greater absorption compared to conventional formulations.

• Superior Bioavailability — Organic magnesium forms, with gluconate ranking highest, achieve absorption rates of 50% to 67% compared to lower absorption for inorganic forms.

• Gentle on Digestion — Magnesium gluconate is widely utilized in pharmaceutical and nutraceutical formulations due to its high bioavailability and excellent gastrointestinal tolerability.

• Synergistic Gluconate Activity — Magnesium gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to magnesium sulfate, suggesting additional anti-radical and cytoprotective activities.

• Cardiovascular Support — Magnesium gluconate has been studied in the prevention of pregnancy-induced hypertension, with low-dose magnesium gluconate treatment showing a 4% incidence of PIH versus 16% in the control group (P < 0.05).

• Stress Modulation — The increase of magnesium concentration in serum achieved by magnesium gluconate was higher than that due to magnesium chloride, and the substance causes a significant reduction in the increase in catecholamine and corticosterone concentration in serum under stress conditions.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The usual adult dose of magnesium gluconate as a dietary supplement is 500 to 1,000 mg (27 to 54 mg elemental magnesium) orally once a day. Magnesium gluconate is also available in tablet and liquid forms, usually taken two to four times a day depending on the condition. For liposomal magnesium gluconate formulations, commercial products typically recommend a dose of 7.5 mL once daily, providing 100 mg of magnesium from gluconate and bisglycinate, dissolved in water or juice. The Tolerable Upper Intake Level (UL) for supplemental magnesium is 350 mg per day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.