Product Detailed Description

Liposomal Vitamin B5 DL-Panthenol 70% — High Bioavailability Provitamin B5 Supplement

Product Overview

liposomal Vitamin B5 DL-Panthenol 70% is a premium-grade dietary supplement ingredient delivering DL-panthenol in an advanced liposomal delivery system. DL-Panthenol (CAS 16485-10-2), also known as DL-pantothenol, DL-pantothenyl alcohol, or (±)-α,γ-dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide, is the racemic mixture of D- and L-panthenol, the alcohol analog of pantothenic acid (vitamin B5). It is chemically characterized by the molecular formula C₉H₁₉NO₄ and a molecular weight of 205.25 g/mol. The compound is a member of the B complex vitamins and is an essential component for normally functioning epithelium.

DL-Panthenol is a provitamin B5 that is enzymatically oxidized in the body to pantothenic acid, which is then phosphorylated and incorporated into coenzyme A (CoA). CoA is a central metabolic cofactor required for the tricarboxylic acid (TCA) cycle, fatty acid synthesis, and the metabolism of carbohydrates and proteins. Beyond energy production, pantothenic acid is essential for the synthesis of cholesterol, steroid hormones, and the neurotransmitter acetylcholine, making it a critical component for maintaining physiological homeostasis across various organ systems. In dermatological applications, DL-panthenol acts as a humectant, emollient, and skin barrier repair agent, providing deep moisturizing, promoting wound healing, reducing inflammation, and soothing irritation.

Why Liposomal Technology?

Conventional vitamin B5 supplementation faces significant pharmacokinetic challenges. The primary absorption mechanism for pantothenic acid and its derivatives is the sodium-dependent multivitamin transporter (SMVT), which is saturable and exhibits dose-dependent absorption kinetics. At higher doses, SMVT becomes saturated, and absorption efficiency declines, limiting systemic bioavailability. Additionally, pantothenic acid is sensitive to heat and acidic or alkaline conditions, with industrial and domestic processing capable of degrading up to 80% of the vitamin’s activity.

Liposomal encapsulation provides four critical advantages:

1. Bypass of SMVT Saturation — Liposomal encapsulation offers a biomimetic “Trojan horse” delivery mechanism that protects vitamin B5 from the acidic gastric environment. By utilizing a phospholipid bilayer, this technology enables non-saturable absorption pathways such as passive diffusion, endocytosis, and lymphatic uptake, effectively bypassing the competitive limitations of SMVT and the hepatic first-pass effect.

2. Enhanced Encapsulation Efficiency and Protection — Liposomal formulations achieve high encapsulation efficiencies for panthenol derivatives. The encapsulation efficiency of the optimized formulation for D-panthenyl triacetate (PTA) was found to be 87.84% ± 4.61%. Encapsulation protects DL-Panthenol from degradation, increasing its shelf-life and stability in formulations.

3. Enhanced Stability and Controlled Release — The phospholipid bilayer acts as a protective shell, effectively preventing active ingredients from degrading due to light, oxidation, or pH changes. Liposomal encapsulation offers enhanced stability and controlled release for DL-Panthenol in nanoparticle-based drug delivery systems.

4. Enhanced Cellular Uptake and Tissue Delivery — liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism is particularly advantageous for supporting skin barrier repair, tissue regeneration, and metabolic management through enhanced coenzyme A synthesis.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% DL-panthenol in the liposomal formulation, with ≥99% assay available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 87.84% ± 4.61% encapsulation efficiency for panthenol derivatives, protects from gastric degradation, and enhances intestinal absorption through non-saturable pathways.

• Provitamin B5 Activity — DL-Panthenol is enzymatically converted to pantothenic acid, the precursor to coenzyme A (CoA), which is essential for the Krebs cycle and fatty acid metabolism.

• Skin Barrier and Moisturization — DL-Panthenol provides deep moisturizing, supports hydration, and strengthens the skin‘s natural barrier function.

• Wound Healing and Anti-Inflammatory — Promotes wound healing, reduces inflammation, and soothes irritation.

• Hair and Scalp Health — Enhances hair strength, flexibility, and shine.

• Clinically Established for Skin Barrier Repair — The presence of panthenol in semisolid formulations significantly enhances skin barrier repair and hydration of the stratum corneum.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

For topical applications, DL-Panthenol usage rates typically range from 0.5% to 5%. Specific recommended levels include: rinse-off hair conditioner 1–5%; leave-in hair conditioner 0.1–0.5%; hair tonic/serum 0.3–1.0%; facial and body lotions 0.2–1.0%; anti-aging serum 0.4–2%; after-sun lotions 0.5–2.0%. For oral supplementation, commercial panthenol tablets provide 100 mg per tablet, with typical dosing of 1–3 tablets daily (100–300 mg/day). Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and sustained release.

Important Safety Information: DL-Panthenol is generally well tolerated. It is widely used in cosmetic and personal care products. Individuals with known hypersensitivity to panthenol or pantothenic acid should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. Rare cases of contact dermatitis have been reported with topical dexpanthenol.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.