Product Detailed Description

liposomal Vitamin B9 Folic Acid 70% — High Bioavailability Vitamin B9 Supplement

Product Overview

Liposomal Vitamin B9 Folic Acid 70% is a premium-grade dietary supplement ingredient delivering folic acid in an advanced liposomal delivery system. Folic acid (CAS 59-30-3), also known as vitamin B9, pteroylglutamic acid, or vitamin M, is a water-soluble B-complex vitamin with the molecular formula C₁₉H₁₉N₇O₆ and a molecular weight of 441.40 g/mol. The compound is chemically designated as N-[p-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. Folic acid occurs as a yellow to orange-yellow crystalline powder that is practically insoluble in water and ethanol, but is readily soluble in dilute alkaline solutions. It is stable in air but is sensitive to light and oxidation.

Folic acid is the synthetic, stable form of folate that is used in dietary supplements and food fortification. Folate is the natural form of vitamin B9 found in foods, while folic acid is the oxidized, monoglutamate form that is more stable and better absorbed than natural food folates. Folic acid is essential for numerous physiological functions, including DNA synthesis and repair, red blood cell formation, amino acid metabolism, and the regulation of homocysteine levels. The importance of folic acid in prenatal health is well established, with adequate intake before and during early pregnancy significantly reducing the risk of neural tube defects.

Why Liposomal Technology?

Conventional folic acid presents significant bioavailability challenges. The compound has poor water solubility, is easily destroyed in gastric acid, and has low absorption and utilization rate in the human body. Folic acid absorption occurs primarily in the proximal small intestine through a saturable active transport mechanism, and at higher doses, this transporter becomes saturated, limiting systemic bioavailability.

Liposomal encapsulation provides four critical advantages:

1. Maximized Bioavailability — Liposomes shield folic acid from gastric acid, which often reduces the potency of standard B9. The lipid shell facilitates direct cellular uptake, ensuring more folate reaches the bloodstream. Liposomal delivery systems significantly improve oral absorption by protecting the vitamin from gastric degradation and first-pass hepatic metabolism.

2. Molecular Protection — As folic acid is sensitive to light and oxidation, the phospholipid bilayer acts as a stable barrier, maintaining the nutrient‘s concentration and structural integrity throughout storage. This protection ensures that the folic acid remains stable and active until it reaches the absorption site.

3. Gentle and Non-Irritating — The encapsulation prevents direct chemical interaction with the sensitive gastric mucosa, making it ideal for high-dosage prenatal or therapeutic regimens without causing gastrointestinal distress.

4. High Cellular Affinity — Because liposomes are biologically similar to human cells, they fusion-deliver vitamin B9 more precisely to cell sites where DNA repair and replication occur. This targeted delivery enhances the efficiency of folate utilization at the cellular level.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% folic acid loading in the liposomal formulation, with USP/FCC/EP-grade assay of 97.0%–102.0% on anhydrous basis available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation shields folic acid from gastric acid, facilitates direct cellular uptake, and ensures more folate reaches the bloodstream.

• Clinically Validated for Neural Tube Defect Prevention — Adequate folic acid intake before and during early pregnancy significantly reduces the risk of neural tube defects such as spina bifida and anencephaly.

• Red Blood Cell Production — Participates in hemoglobin synthesis and the maturation and division of red blood cells, helping treat megaloblastic anemia caused by folic acid deficiency.

• Cardiovascular Support — Helps lower homocysteine concentrations in the blood, reduces damage to the vascular endothelium, and maintains vascular elasticity and patency.

• DNA Synthesis and Cellular Metabolism — As a key coenzyme in DNA and RNA synthesis, folic acid participates in the division, proliferation, and metabolism of all human cells.

• Nervous System Health — Participates in neurotransmitter synthesis and the maintenance of nerve myelin sheaths, ensuring normal nerve signal transmission.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for folate is 400 mcg DFE/day for adults. Women who are planning pregnancy or could become pregnant should take 400–800 mcg of folic acid per day before becoming pregnant, and 600–1,000 mcg per day throughout pregnancy. The Centers for Disease Control and Prevention (CDC) recommends that all women capable of becoming pregnant should get 400 micrograms (mcg) of folic acid daily. For supplemental use, many prenatal and multivitamin supplements provide 400–800 mcg of folic acid. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and protection from gastric degradation.

Important Safety Information: Folic acid is generally well tolerated at recommended doses. The Tolerable Upper Intake Level (UL) for folic acid from supplements is 1,000 mcg/day for adults. High-dose folic acid supplementation may mask vitamin B12 deficiency, and individuals with known vitamin B12 deficiency should consult a healthcare professional before use. Folic acid may interact with certain medications, including methotrexate, phenytoin, and sulfasalazine. Pregnant or lactating women and children should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.