Product Detailed Description

Liposomal vitamin B7 D-Biotin 70% — High Bioavailability Vitamin B7 Supplement

Product Overview

liposomal Vitamin B7 D-Biotin 70% is a premium-grade dietary supplement ingredient delivering D-biotin in an advanced liposomal delivery system. D-Biotin (CAS 58-85-5), also known as vitamin B7, vitamin H, or coenzyme R, is a water-soluble B-complex vitamin with the molecular formula C₁₀H₁₆N₂O₃S and a molecular weight of 244.31 g/mol. The compound is a bicyclic derivative consisting of an imidazolidone ring fused to a tetrahydrothiophene ring bearing a valeric acid side chain. D-Biotin occurs as white to off-white crystalline powder that is soluble in hot water, dimethyl sulfoxide, alcohol, and benzene. Its maximum aqueous solubility is approximately 22 mg/100 mL at 25°C, and it is practically insoluble in acetone. D-Biotin has a specific rotation of +89° to +93° and a melting point of 232–233°C.

D-Biotin is a growth factor present in minute amounts in every living cell and plays a role in numerous naturally occurring metabolic reactions. Biotin is the essential cofactor for biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin and must obtain it through dietary intake. The richest dietary sources of biotin include meat, fish, eggs, organ meats (such as liver), seeds, nuts, sweet potatoes, spinach, and broccoli. The recommended daily intake for adults is 30 mcg per day.

Why Liposomal Technology?

Conventional D-biotin presents significant bioavailability challenges. The compound has low aqueous solubility (approximately 22 mg/100 mL at 25°C), which limits its dissolution rate and absorption following oral administration. D-Biotin absorption occurs primarily in the small intestine through a saturable active transport mechanism (the sodium-dependent multivitamin transporter, SMVT), and at higher doses, this transporter becomes saturated, limiting systemic bioavailability.

Liposomal encapsulation provides four critical advantages:

1. Significantly Enhanced Solubility and Bioavailability — Liposomal biotin formulations significantly improve oral absorption by substantially increasing solubility. The phospholipid bilayer converts the poorly water-soluble crystalline D-biotin into a water-dispersible form that is readily absorbed. Nano-liposomal biotin formulations have been developed specifically for stabilizing and increasing the solubility of biotin, a water-soluble active material with low solubility. Biotin nano-liposomes with improved solubility and reduced precipitation problems have been successfully manufactured with particle sizes of 100–250 nm and zeta potentials of −80 to −30 mV.

2. Enhanced Cellular Uptake and Tissue Delivery — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This bypasses the saturable SMVT transport mechanism that limits conventional biotin absorption and supports enhanced systemic absorption and tissue distribution. The phospholipid bilayer protects biotin from premature degradation during digestive transit and facilitates direct cellular uptake.

3. Enhanced Stability and Controlled Release — The phospholipid bilayer shields D-biotin from gastric degradation and premature metabolism, preserving its intact molecular structure until reaching optimal absorption sites in the small intestine. Liposomal delivery provides a sustained-release profile that maintains steady plasma levels of biotin, supporting prolonged carboxylase cofactor activity rather than a sharp peak followed by rapid renal excretion.

4. Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems compared to crystalline D-biotin; suitable for capsules, tablets, powder drink mixes, and functional beverages. This expands formulation flexibility for liquid and functional food applications.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% D-biotin in the liposomal formulation, with USP/FCC/EP-grade assay of 98.0%–102.0% on dried basis available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation significantly improves oral absorption by substantially increasing solubility and enables non-saturable absorption pathways, bypassing SMVT saturation.

• Carboxylase Cofactor — D-Biotin is the essential cofactor for acetyl-CoA carboxylase (fatty acid synthesis), pyruvate carboxylase (gluconeogenesis), propionyl-CoA carboxylase (amino acid catabolism), and β-methylcrotonyl-CoA carboxylase (leucine catabolism).

• Clinically Validated for Hair and Nail Health — A randomized, double-blind, placebo-controlled clinical trial in 105 participants demonstrated that biotin supplementation (1.25 mg/day for 90 days) significantly reduced hair fall (p<0.001), increased hair growth rate by 0.55 mm/day (p<0.0001), reduced nail roughness (p<0.0001), and increased skin elasticity (p<0.0001) with no adverse events reported.

• Energy Metabolism Support — Biotin helps convert the carbohydrates, fats, and proteins in food into energy the body needs, and contributes to normal energy-yielding metabolism.

• Biotin Deficiency Prevention — D-Biotin is used to prevent and treat biotin deficiency, which can cause thinning hair, hair loss, a rash around the eyes, nose, mouth, and anal area, high levels of acid in the blood and urine, seizures, skin infection, brittle nails, and nervous system disorders.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Adequate Intake (AI) for biotin is 30 mcg/day for adults 19 years and older, increasing to 35 mcg/day during breastfeeding. For supplemental use, D-biotin is commonly used at 1,000–10,000 mcg (1–10 mg) per day for hair, skin, and nail support. A randomized, double-blind, placebo-controlled clinical trial in 105 participants used 1.25 mg/day of biotin for 90 days and demonstrated significant improvements in hair fall, hair growth rate, nail roughness, and skin elasticity with no adverse events reported. There is no established tolerable upper intake level (UL) for biotin due to its low toxicity. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and bypass of SMVT saturation.

Important Safety Information: D-Biotin is generally well tolerated. It is a water-soluble vitamin, and excess amounts are excreted in the urine. No tolerable upper intake level (UL) has been established for biotin due to its low toxicity. High-dose biotin supplementation may interfere with certain laboratory tests, including immunoassays for thyroid hormones (TSH, T3, T4), cardiac troponin, and other biomarkers, potentially leading to falsely low or falsely high results. Individuals should inform their healthcare provider about biotin supplementation before undergoing laboratory testing. Pregnant or lactating women and children should consult a healthcare professional before use.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.