Product Detailed Description

Liposomal vitamin A Palmitate 300K IU — High Bioavailability Vitamin A Supplement

Product Overview

liposomal Vitamin A Palmitate 300K IU is a premium-grade dietary supplement ingredient delivering retinyl palmitate in an advanced liposomal delivery system. Retinyl palmitate (CAS 79-81-2), also known as vitamin A palmitate, all-trans-retinyl palmitate, or retinol palmitate, is the hexadecanoate ester of all-trans-retinol, chemically characterized by the molecular formula C₃₆H₆₀O₂ and a molecular weight of 524.86 g/mol. It occurs as a light yellow solid or yellow oily liquid that is insoluble in water but soluble in hydrocarbons, chlorinated hydrocarbons, ethers, fats, and oils.

Retinyl palmitate is the most stable ester form of preformed vitamin A and is the most common form of vitamin A used for dietary supplementation. It is a naturally occurring phenyl analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Vitamin A is an essential fat-soluble micronutrient required for vision, immune function, reproduction, and cellular differentiation. Retinyl palmitate is preferred over other vitamin A forms for food fortification and supplement applications due to its stability and bioavailability.

Why Liposomal Technology?

Conventional retinyl palmitate presents significant formulation challenges. The compound is highly susceptible to oxidative degradation and is sensitive to air, heat, and light. Its hydrophobic nature makes administration difficult by either intravenous or oral routes, requiring the utilization of oily formulations or surfactant-containing aqueous solutions. The therapeutic use of retinoids is further limited by many adverse effects, including strong toxicity (hypervitaminosis) and poor chemical stability.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability — liposome-encapsulated vitamin A compounds exhibit greater stability compared to free forms. Absorption and fluorescence studies of retinol palmitate intercalated in phosphatidylcholine liposomes show that these compounds are bound to the lipid bilayer, which protects them from oxidative degradation and environmental stressors. Incorporation of cholesterol and vitamin A palmitate into the liposome structure increased the zeta potential from −29 to −58 mV, significantly improving electrostatic stability and preventing particle aggregation during storage.

2. Diminished Toxicity — Liposomal delivery reduces blood viscosity and causes less lysis of red blood cells than retinoid compounds not complexed in liposomes. This improved safety profile is particularly important for vitamin A, which can cause hypervitaminosis A with symptoms including dizziness, nausea, headaches, and liver damage at excessive doses.

3. Enhanced Bioavailability — Nanoliposomal vitamin A palmitate greatly improves the dispersion and stability of vitamin A, significantly enhancing the dissolution rate and bioavailability of bioactive substances. Nanoliposomal Vitamin A Palmitate enhances the absorption and bioavailability of vitamin A, effectively protects sensitive components, and strengthens stability during processing. The liposomal delivery system acts as a protective layer, enhancing the absorption and bioavailability of vitamin A palmitate.

4. Water Dispersibility — Liposomal vitamin A palmitate can be formulated to be 100% water-soluble and 100% oil-soluble (amphiphilic), greatly expanding formulation flexibility for functional beverages, liquid supplements, and aqueous food applications.

Product Specifications

Key Features

• High Purity — Standardized to 300,000 IU/g of vitamin A palmitate activity, with higher potencies available for concentrated applications.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves particle sizes of 76–115 nm with monomodular distribution, and incorporation of cholesterol and vitamin A palmitate increases zeta potential from −29 to −58 mV for superior electrostatic stability.

• Diminished Toxicity — Liposomal delivery reduces blood viscosity and causes less red blood cell lysis compared to free retinoid compounds.

• Amphiphilic Formulation — Liposomal vitamin A palmitate can be formulated to be 100% water-soluble and 100% oil-soluble, greatly expanding application flexibility.

• Enhanced Bioavailability — Nanoliposomal vitamin A palmitate greatly improves the dispersion and stability of vitamin A, significantly enhancing the dissolution rate and bioavailability of bioactive substances.

• Food Fortification Ready — Retinyl palmitate is widely used for fortifying fatty foods such as margarine, spreads, oils, milk, and dairy products, with typical addition levels of 3–9 mg (10,000–30,000 IU) of vitamin A per kg of margarine.

• USP/EP Compliant — Product complies with the current "Vitamin A concentrate (oily form), synthetic" Ph.Eur. and "Vitamin A" USP monographs.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for vitamin A is 900 μg RAE/day (3,000 IU) for adult males and 700 μg RAE/day (2,330 IU) for adult females. The Tolerable Upper Intake Level (UL) for preformed vitamin A is 3,000 μg RAE/day (10,000 IU) for adults to prevent teratogenic effects and liver damage. For food fortification of margarine, quantities of 3–9 mg (10,000–30,000 IU) of vitamin A calculated as retinol are usually added per kg of margarine. For edible oil fortification, recommendations range from about 30,000 to 100,000 IU/kg (9–30 mg RE/kg). Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: Vitamin A is a fat-soluble vitamin, and excess intake can lead to hypervitaminosis A, causing symptoms like dizziness, nausea, headaches, and liver damage. Not recommended in high doses during pregnancy, as it may cause birth defects. Studies indicate that levels of Vitamin A in excess of 1,200 mcg daily can increase the incidence of birth defects or other reproductive harm. Pregnant or lactating women should consult a healthcare professional before use. Individuals taking anticoagulant medications or with liver conditions should consult a healthcare professional before supplementation.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.