Product Detailed Description

liposomal Beta-Carotene 70% — High Bioavailability Provitamin A Supplement

Product Overview

Liposomal Beta-Carotene 70% is a premium-grade dietary supplement ingredient delivering beta-carotene in an advanced liposomal delivery system. Beta-carotene (CAS 7235-40-7), also known as β,β-carotene or provitamin A, is a naturally occurring tetraterpenoid carotenoid pigment with the molecular formula C₄₀H₅₆ and a molecular weight of 536.87 g/mol. It is an orange-yellow, fat-soluble compound that occurs naturally in carrots, sweet potatoes, spinach, and other colorful fruits and vegetables. β-Carotene is characterized by its long, conjugated polyene chain, which is responsible for its intense color and potent antioxidant activity.

β-Carotene is the most abundant and most potent provitamin A carotenoid in the human diet, serving as the primary dietary precursor to vitamin A (retinol). The conversion of β-carotene to retinol occurs in the intestinal mucosa and liver via the enzyme β-carotene 15,15'-monooxygenase. In addition to its provitamin A activity, β-carotene functions as a potent lipid-soluble antioxidant, quenching singlet oxygen and scavenging peroxyl radicals to protect cellular membranes from oxidative damage.

Why Liposomal Technology?

Conventional β-carotene presents significant formulation challenges. The compound is highly hydrophobic and practically insoluble in water, which limits its dispersibility in aqueous systems and its absorption following oral administration. β-Carotene is also highly sensitive to environmental stressors: free β-carotene degrades readily during storage, particularly when exposed to high temperature and UV light. Microencapsulated forms can mitigate 20–40% thermal and photo-degradation, but standard formulations still face significant stability challenges. Additionally, the crystalline structure of β-carotene limits its dissolution and bioavailability.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Stability and Protection — The phospholipid bilayer shields β-carotene from oxygen, light, and heat-induced degradation. Liposomal β-carotene formulations preserve more than 90% of the incorporated β-carotene for 60 days of refrigerated storage under vacuum, significantly outperforming standard formulations. The phospholipid carrier itself provides intrinsic oxidative shielding without relying on high-dose synthetic antioxidants.

2. Enhanced Water Dispersibility and Bioavailability — Liposomal β-carotene transforms a hydrophobic crystalline compound into a water-dispersible, oxidation-protected ingredient designed for consistent performance from manufacturing to consumption. Encapsulation efficiency is verified at ≥85% via dialysis/HPLC, confirming genuine vesicle loading rather than simple phospholipid blending.

3. Verified Nano-Scale Consistency — Dynamic Light Scattering (DLS) confirms particle sizes of 80–300 nm with polydispersity index (PDI) ≤0.35, ensuring consistent vesicle formation across every batch and predictable per-unit dosing across production runs.

4. Cleaner Formulation with Intrinsic Protection — With the phospholipid bilayer handling oxidation protection, formulators can reduce synthetic antioxidant loads, supporting cleaner Supplement Facts panels and more compelling brand transparency without compromising stability targets.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% β-carotene by HPLC, ensuring consistent active content.

• Liposomal Enhancement — Phospholipid bilayer encapsulation preserves >90% of β-carotene for 60 days of refrigerated storage, with EE% ≥85% verified via dialysis/HPLC and DLS-confirmed particle sizes of 80–300 nm (PDI ≤0.35).

• Provitamin A Precursor — 3.8 mg of β-carotene is equivalent to 1 mg of retinol, making it the most potent dietary provitamin A carotenoid.

• Potent Antioxidant Activity — β-Carotene quenches singlet oxygen and scavenges peroxyl radicals, protecting cell membranes from oxidative damage and supporting the body's defense against reactive oxygen species.

• Superior Isomer Stability — Natural algal isomer mixtures containing approximately 50:50 all-trans:9-cis demonstrate ≥10× higher liver tissue deposition compared to synthetic all-trans-rich forms, while synthetic forms provide consistent vitamin A equivalence for food fortification.

• Clinically Studied for Erythropoietic Protoporphyria — β-Carotene has been clinically used for the management of erythropoietic protoporphyria at doses ranging from 60–300 mg/day depending on age, demonstrating its therapeutic potential for photosensitivity disorders.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems compared to crystalline β-carotene; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The typical dietary intake of β-carotene in Germany is within the desirable intake levels of 2–4 mg per day mentioned by nutrition societies. The German Federal Institute for Risk Assessment (BfR) recommends not adding more than 3.5 mg of β-carotene per daily dose to a food supplement. The RDA for β-carotene is 2.25–7.8 mg/day. For general supplementation, do not take more than 7 mg of β-carotene supplements per day unless advised by a general practitioner. For specific therapeutic applications such as erythropoietic protoporphyria, clinically supervised doses range from 60–90 mg/day for children aged 1–4 to 300 mg/day for adults over 16. Evidence indicates that consumption of up to 50 mg/day β-carotene does not present safety concerns for the non-smoking general population. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: High-dose β-carotene supplementation (20 mg/day or more) has been associated with an increased risk of lung cancer in heavy smokers. Individuals who smoke or have a history of asbestos exposure should avoid high-dose β-carotene supplementation without medical supervision. Pregnant or lactating women and children should consult a healthcare professional before use. β-Carotene may interact with certain medications, and individuals with liver conditions should consult a healthcare professional before supplementation.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.