Product Detailed Description

Liposomal vitamin A Retinyl Acetate Microcapsule Powder 300K IU — High Stability Vitamin A Supplement

Product Overview

liposomal Vitamin A Retinyl Acetate Microcapsule Powder 300K IU is a premium-grade dietary supplement ingredient delivering retinyl acetate in an advanced dual-encapsulation delivery system. Retinyl acetate (CAS 127-47-9), also known as vitamin A acetate, all-trans-retinyl acetate, or retinol acetate, is the acetate ester of all-trans-retinol, chemically characterized by the molecular formula C₂₂H₃₂O₂ and a molecular weight of 328.49 g/mol. It occurs as a light yellow crystalline powder or supercooled liquid that is practically insoluble in water but soluble in ethanol, chloroform, and oils.

Retinyl acetate is the most stable ester form of preformed vitamin A and is one of the most widely used forms of vitamin A in dietary supplements and food fortification. It is the preferred form for dry food applications due to its superior stability compared to retinol. The microencapsulated cold-water dispersible (CWS) form is specifically designed for fortification of dry food products such as flour, milk powder, and beverage powder, where it provides excellent flowability and dispersibility without the need for gelatin.

Why Liposomal Microcapsule Technology?

Native retinyl acetate presents significant formulation challenges. The compound is highly susceptible to oxidative degradation and is sensitive to moisture, oxygen, heat, and light. Stability studies demonstrate that a spray-dried powder of retinyl acetate (1×10⁶ IU/g) had a shelf-life of 24 months when stored at 15°C, while recovery dropped to 72% at 35°C. Additionally, free retinyl acetate is not water-soluble, limiting its application in aqueous food matrices and liquid formulations.

The dual-encapsulation technology provides four critical advantages:

1. Exceptional Stability and Extended Shelf-Life — The microencapsulation matrix, composed of gum arabic, sucrose, corn starch, and sodium ascorbate, forms a protective barrier that shields retinyl acetate from oxidative degradation, moisture, and light exposure. This microencapsulation technology enables a shelf-life of 24 months in unopened original packaging, with stability data demonstrating only ~10% loss after 3 months and ~21% loss after 6 months in premixure applications at ambient temperature.

2. Cold-Water Dispersibility — The microcapsule powder disperses in cool water to form a milky emulsion, enabling incorporation into aqueous formulations that would otherwise be incompatible with fat-soluble retinyl acetate.

3. Liposomal Enhancement of Bioavailability — The liposomal phospholipid bilayer further enhances the bioavailability of retinyl acetate by protecting it during digestive transit and facilitating efficient cellular uptake. Liposomal formulations have been shown to increase the relative bioavailability of vitamin A compounds by up to 2.36-fold compared to conventional forms.

4. Antioxidant Protection System — The formulation includes sodium ascorbate and dl-α-tocopherol as antioxidants, providing intrinsic oxidative protection without relying on high-dose synthetic antioxidants.

Product Specifications

Key Features

• High Potency — Standardized to 300,000 IU/g of vitamin A acetate activity, with multi-potency grades available from 250,000 IU/g to 2,800,000 IU/g for customized fortification demands.

• Dual-Encapsulation Technology — Microencapsulation within a gum arabic/sucrose/corn starch matrix combined with liposomal phospholipid bilayer protection provides exceptional stability and enhanced bioavailability.

• Cold-Water Dispersible — Disperses in cool water to form a milky emulsion, enabling use in aqueous formulations and dry food products.

• 24-Month Shelf-Life — Stability data demonstrates a shelf-life of 24 months when stored at 15°C, with only ~10% loss after 3 months and ~21% loss after 6 months in premixure applications at ambient temperature.

• Antioxidant Protection System — Formulated with sodium ascorbate and dl-α-tocopherol as antioxidants for intrinsic oxidative protection.

• Gelatin-Free Formulation — Suitable for vegetarian, vegan, and clean-label applications.

• Food Fortification Ready — Ideal for fortification of dry food products including flour, milk powder, and beverage powder.

• Excellent Flowability — Light-yellow, free-flowing microcapsule powder with no odor, suitable for direct compression or powder mixing.

• USP/EP Compliant — Complies with the current "Vitamin A concentrate (powder form), synthetic" Ph.Eur. and "Vitamin A" USP monographs.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for vitamin A is 900 μg RAE/day (3,000 IU) for adult males and 700 μg RAE/day (2,330 IU) for adult females. The Tolerable Upper Intake Level (UL) for preformed vitamin A is 3,000 μg RAE/day (10,000 IU) for adults to prevent teratogenic effects and liver damage. In Canada, oral dosage forms providing not greater than 10,000 IU/day of vitamin A activity are permitted as Natural Health Products, and above 10,000 IU/day, vitamin A is classified as a prescription drug. For food fortification, typical levels range from 2,000–5,000 IU/100 g for flour and cereal products, and 2,000–4,000 IU/100 g for milk powder. Liposomal microcapsule formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: Vitamin A is a fat-soluble vitamin, and excess intake can lead to hypervitaminosis A, causing symptoms including dizziness, nausea, headaches, and liver damage. Not recommended in high doses during pregnancy, as it may cause birth defects. Studies indicate that levels of vitamin A in excess of 1,200 mcg daily can increase the incidence of birth defects or other reproductive harm. Pregnant or lactating women should consult a healthcare professional before use. Individuals taking anticoagulant medications or with liver conditions should consult a healthcare professional before supplementation.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.