Product Detailed Description

Liposomal vitamin B2 Riboflavin 70% — High Bioavailability Vitamin B2 Supplement

Product Overview

liposomal Vitamin B2 Riboflavin 70% is a premium-grade dietary supplement ingredient delivering riboflavin in an advanced liposomal delivery system. Riboflavin (CAS 83-88-5), also known as vitamin B2, lactoflavin, or 7,8-dimethyl-10-(1-D-ribityl)-benzo[g]pteridin-2,4-dione, is a water-soluble vitamin with the molecular formula C₁₇H₂₀N₄O₆ and a molecular weight of 376.36 g/mol. It comprises a tricyclic, nitrogen-containing isoalloxazine ring system with a ribitol side-chain at N10, and occurs as a yellow to orange-yellow crystalline powder that crystallizes in sharp, optically active needles and melts with decomposition at 275–282°C. Riboflavin is sparingly soluble in water with a yellow-green fluorescence, very sparingly soluble in ethanol, and insoluble in other organic solvents. In neutral or acid solutions it is more stable, even against heat and atmospheric oxygen, but it is highly unstable in alkaline media and when exposed to ultraviolet and visible light.

Riboflavin is an essential micronutrient that serves as the precursor to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are prosthetic groups in more than 100 enzymes in the plant and animal kingdoms. These flavoproteins belong to the enzymatic class of oxidoreductases and are indispensable for cellular energy production, fatty acid oxidation, redox balance, and DNA damage responses. Riboflavin deficiency is rare in the United States, but certain groups are at higher risk, including athletes who are strict vegetarians, pregnant and breastfeeding women, people who avoid dairy foods, and individuals with riboflavin transporter deficiency.

Why Liposomal Technology?

Conventional riboflavin presents significant formulation and bioavailability challenges. The compound is highly photosensitive and is irreversibly degraded by visible and ultraviolet light to lumiflavin (under alkaline conditions) or lumichrome (under acidic conditions), both of which are biologically inactive. In milk stored in daylight, the riboflavin content decreases by more than 80% within hours, and processing losses in foods are approximately 20%. Additionally, the body cannot absorb more than about 27 mg of riboflavin at a time due to saturable active transport mechanisms, and the hydrophilic nature of riboflavin causes rapid clearance from the bloodstream and low intracellular absorption, reducing its therapeutic efficacy.

Liposomal encapsulation provides four critical advantages:

1. Dramatically Enhanced Photostability — A study published in the Journal of Photochemistry and Photobiology B demonstrated that liposomal preparations of riboflavin significantly stabilize the compound against photodegradation. The apparent first-order rate constants for riboflavin degradation (1.73–2.29 × 10⁻³ min⁻¹) decreased linearly with increasing phosphatidylcholine concentration in the range of 12.15 to 14.85 mM, indicating that higher PC concentrations in liposomes lead to greater riboflavin stability. Fluorescence measurements indicate excited singlet state quenching and the formation of a charge-transfer complex between riboflavin and phosphatidylcholine, resulting in electron transfer from PC to riboflavin that causes photoreduction and stabilization of the vitamin.

2. Enhanced Encapsulation Efficiency and Sustained Delivery — Liposomal riboflavin formulations achieve entrapment efficiencies of 26–42% using standard preparation methods. Optimized liposomal preparations using sucrose-lipid mass ratios of 1:1 achieved riboflavin encapsulation efficiencies of up to 78%. The liposomal delivery system protects riboflavin during digestive transit and facilitates efficient cellular uptake through lipid-mediated pathways, bypassing the saturable active transport mechanisms that limit conventional riboflavin absorption.

3. Reduced Photodegradation and Enhanced Formulation Stability — The phospholipid bilayer shields riboflavin from light-induced degradation, preserving its intact molecular structure during storage and gastrointestinal transit. Dynamic light scattering and atomic force microscopy have confirmed the physical characteristics and stability of liposomal riboflavin preparations.

4. Enhanced Cellular Uptake and Bioavailability — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. The hydrophilic nature of free riboflavin causes rapid clearance from the bloodstream and low intracellular absorption, reducing its therapeutic efficacy, and liposomal encapsulation addresses this limitation by providing a protective carrier that enhances cellular delivery.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% riboflavin in the liposomal formulation, with USP/EP/JP-grade assay of 98.0%–102.0% on dried basis available.

• Liposomal Enhancement — Liposomal encapsulation significantly enhances photostability, with degradation rate constants decreasing linearly with increasing phosphatidylcholine concentration. Entrapment efficiencies of 26–42% with standard methods, up to 78% with optimized sucrose-lipid ratios.

• Energy Metabolism Support — Riboflavin is the precursor to FMN and FAD, essential coenzymes in the mitochondrial electron transport chain and TCA cycle, supporting ATP production from carbohydrates, fats, and proteins.

• Antioxidant Defense — FAD is a cofactor for glutathione reductase, which regenerates reduced glutathione, the body‘s master antioxidant. Riboflavin also supports the activity of glutathione peroxidase.

• Homocysteine Regulation — FAD is a cofactor for methylenetetrahydrofolate reductase (MTHFR), the enzyme that converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine.

• Clinically Validated for Migraine Prophylaxis — High-dose riboflavin (400 mg/day) has demonstrated efficacy in reducing migraine frequency, with evidence supporting its use as a prophylactic agent in both adults and children.

• Superior Stability — Liposomal encapsulation protects riboflavin from light-induced degradation to lumiflavin and lumichrome, preserving its biological activity during storage and digestive transit.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for riboflavin is 1.3 mg/day for adult men and 1.1 mg/day for adult women. During pregnancy, the requirement increases to 1.4 mg/day, and during breastfeeding to 1.6 mg/day. The body cannot absorb more than approximately 27 mg of riboflavin at a time, and excess riboflavin is excreted in the urine. For supplemental use, many B-complex and multivitamin supplements provide 10–100 mg of riboflavin. For migraine prophylaxis, clinical studies have used 400 mg/day in adults and 200–400 mg/day in children under medical supervision. For general energy metabolism and antioxidant support, 10–50 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and cellular delivery.

Important Safety Information: Riboflavin is generally well tolerated. It is a water-soluble vitamin, and excess amounts are excreted in the urine, giving it a bright yellow color. No tolerable upper intake level (UL) has been established for riboflavin due to its low toxicity. Individuals with known hypersensitivity to riboflavin should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. Riboflavin may interact with certain medications, including anticholinergic drugs, tricyclic antidepressants, and probenecid. Riboflavin supplementation may interfere with certain laboratory tests, including fluorometric determinations and urobilinogen measurements.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.