Product Detailed Description

Liposomal Vitamin B6 Pyridoxine Hydrochloride 70% — High Bioavailability Vitamin B6 Supplement

Product Overview

liposomal Vitamin B6 Pyridoxine Hydrochloride 70% is a premium-grade dietary supplement ingredient delivering pyridoxine hydrochloride in an advanced liposomal delivery system. Pyridoxine hydrochloride (CAS 58-56-0), also known as vitamin B6 hydrochloride, pyridoxol hydrochloride, or 5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride, is the hydrochloride salt form of pyridoxine, one of the three natural forms of vitamin B6 (along with pyridoxal and pyridoxamine). It is chemically characterized by the molecular formula C₈H₁₂ClNO₃ and a molecular weight of 205.64 g/mol. The compound occurs as a white to almost white, practically odorless crystalline powder with a bitter and acid taste, freely soluble in water (approximately 20 g per 100 mL), slightly soluble in ethanol, and insoluble in ether and chloroform.

Pyridoxine hydrochloride is the most stable and widely used form of vitamin B6 in dietary supplements and pharmaceutical preparations. It is converted in the body to the active coenzyme form, pyridoxal 5‘-phosphate (PLP), which is essential for red blood cell function, nervous system function, and immune system function, and helps maintain normal blood glucose levels. Vitamin B6 is a cofactor for more than 100 enzymatic reactions, including those involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine), homocysteine regulation, glycogen metabolism, and hemoglobin synthesis.

Why Liposomal Technology?

Conventional vitamin B6 presents significant bioavailability challenges. As a highly water-soluble vitamin with a log P of −4.32, pyridoxine hydrochloride has limited passive permeability across biological membranes. Following oral administration, vitamin B6 absorption occurs primarily through passive diffusion in the jejunum, but its hydrophilic nature limits cellular uptake and tissue distribution. Additionally, vitamin B6 is subject to first-pass metabolism in the liver, which reduces the fraction of active vitamin reaching systemic circulation.

Liposomal encapsulation provides four critical advantages:

1. Enhanced Bioavailability and Cellular Uptake — Liposomal delivery of water-soluble vitamins significantly improves bioavailability by bypassing the stomach environment and first-pass liver metabolism, leading to increased systemic availability. Liposomal formulations achieve up to 90% bioavailability compared to 20–30% in standard forms. The phospholipid bilayer fuses directly with cell membranes, facilitating efficient cellular delivery through lipid-mediated pathways.

2. Protection from Gastric Degradation — The phospholipid bilayer shields pyridoxine hydrochloride from degradation in the acidic gastric environment. Pyridoxine hydrochloride is more stable in acidic to neutral solutions and unstable in alkaline conditions, and liposomal encapsulation provides a protective barrier that preserves biological activity during digestive transit.

3. Sustained Release for Prolonged Biological Activity — Liposomal delivery provides a controlled-release profile that maintains steady plasma levels of pyridoxine and its active metabolite PLP, supporting prolonged enzymatic cofactor activity rather than a sharp peak followed by rapid renal excretion.

4. Enhanced Stability — Liposomal encapsulation protects pyridoxine hydrochloride from light-induced degradation. The compound is stable in air but is slowly affected by sunlight, and liposomal encapsulation provides a protective barrier that preserves stability during storage and formulation.

Product Specifications

Key Features

• High Purity — Standardized to ≥70% pyridoxine hydrochloride in the liposomal formulation, with USP/EP/JP-grade assay of 98.0%–102.0% on dried basis available.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves up to 90% bioavailability compared to 20–30% in standard forms, bypassing gastric degradation and first-pass metabolism.

• Neurotransmitter Synthesis — Vitamin B6 is an essential cofactor for the synthesis of serotonin, dopamine, GABA, and norepinephrine, supporting mood regulation, cognitive function, and nervous system health.

• Homocysteine Regulation — PLP is a cofactor for cystathionine β-synthase and cystathionine γ-lyase in the transsulfuration pathway, supporting healthy homocysteine metabolism.

• Energy Metabolism — Vitamin B6 contributes to normal energy-yielding metabolism and helps reduce tiredness and fatigue.

• Immune Function — Vitamin B6 supports normal immune system function and red blood cell production.

• Hormonal Regulation — Vitamin B6 contributes to the regulation of hormonal activity.

• Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

The Recommended Dietary Allowance (RDA) for vitamin B6 is 1.3 mg/day for adults 19–50 years, increasing to 1.5 mg/day for women and 1.7 mg/day for men over 50 years. During pregnancy, the requirement increases to 1.9 mg/day, and during lactation to 2.0 mg/day. The Tolerable Upper Intake Level (UL) for vitamin B6 from supplements is 100 mg/day for adults, based on the risk of sensory neuropathy at high doses. In China, the daily recommended intake for adults is 1.4–1.6 mg, with a tolerable upper intake level of 60 mg/day. For supplemental use, many B-complex and multivitamin supplements provide 2–25 mg of vitamin B6. Liposomal formulations may provide 5–25 mg of vitamin B6 per serving, with higher doses available for targeted applications. For therapeutic applications, doses up to 200 mg/day have been used under medical supervision. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.

Important Safety Information: Vitamin B6 is generally well tolerated at recommended doses. Prolonged intake of high doses (>200 mg/day) has been associated with peripheral sensory neuropathy, characterized by numbness, tingling, and difficulty walking. The Tolerable Upper Intake Level (UL) for vitamin B6 is 100 mg/day for adults. Individuals with known hypersensitivity to pyridoxine should avoid supplementation. Pregnant or lactating women and children should consult a healthcare professional before use. Vitamin B6 may interact with certain medications, including levodopa, phenytoin, and penicillamine.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.